SAFETY DATA SHEETS
According to Globally Harmonized System of Classification and Labelling of
Chemicals (GHS) - Sixth revised edition
Version: 1.0
Creation Date: Aug 12, 2017
Revision Date: Aug 12, 2017
1.Identification
1.1 GHS Product identifier
Product name quinoline
1.2 Other means of identification
Product number-
Other names Leucol
1.3 Recommended use of the chemical and restrictions on use
Identified
uses
For industry use only. Quinoline is used mainly as an intermediate in the manufacture of other products. Quinoline is also used as a
catalyst, a corrosion inhibitor, in metallurgical processes, in the manufacture of dyes, as a preservative for anatomical specimens, in
polymers and agricultural chemicals, and as a solvent for resins and terpenes. It is also used as an antimalarial medicine.
Uses
advised
against
no data available
1.4 Supplier's details
1.5 Emergency phone number
Emergency phone number-
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).
2.Hazard identification
2.1 Classification of the substance or mixture
Acute toxicity - Oral, Category 4
Acute toxicity - Dermal, Category 4
Skin irritation, Category 2
Eye irritation, Category 2
Germ cell mutagenicity, Category 2
Carcinogenicity, Category 1B
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2
2.2 GHS label elements, including precautionary statements
Pictogram(s)
Signal word Danger
Hazard statement(s)
H302 Harmful if swallowed
H312 Harmful in contact with skin
H315 Causes skin irritation
H319 Causes serious eye irritation
H341 Suspected of causing genetic defects
H350 May cause cancer
H411 Toxic to aquatic life with long lasting effects
Precautionary
statement(s)
Prevention
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P273 Avoid release to the environment.
Response
P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/…if you feel unwell.
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P312 Call a POISON CENTER/doctor/…if you feel unwell.
P321 Specific treatment (see ... on this label).
P362+P364 Take off contaminated clothing and wash it before reuse.
P332+P313 If skin irritation occurs: Get medical advice/attention.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and
easy to do. Continue rinsing.
P337+P313 If eye irritation persists: Get medical advice/attention.
P308+P313 IF exposed or concerned: Get medical advice/ attention.
P391 Collect spillage.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to ...
2.3 Other hazards which do not result in classification
none
3.Composition/information on ingredients
3.1 Substances
Chemical name Common names and synonyms CAS numberEC numberConcentration
quinoline quinoline 91-22-5 none 100%
4.First-aid measures
4.1 Description of necessary first-aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
Fresh air, rest. Refer for medical attention.
In case of skin contact
Remove contaminated clothes. Rinse and then wash skin with water and soap.
In case of eye contact
Rinse with plenty of water (remove contact lenses if easily possible). Refer for medical attention.
If swallowed
Rinse mouth. Give one or two glasses of water to drink. Refer for medical attention .
4.2 Most important symptoms/effects, acute and delayed
Vapors are irritating to nose and throat and may cause headaches, dizziness, and nausea if inhaled. Ingestion causes irritation of mouth and
stomach; vomiting may occur. Contact with eyes or skin causes irritation. (USCG, 1999)
4.3 Indication of immediate medical attention and special treatment needed, if necessary
Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary.
Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat
if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... .
Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong
gag reflex, and does not drool. Administer activated charcoal ... . /Aromatic hydrocarbons and related compounds/
5.Fire-fighting measures
5.1 Extinguishing media
Suitable extinguishing media
EXTINGUISH WITH WATER, DRY CHEMICALS, FOAM, OR CARBON DIOXIDE.
5.2 Specific hazards arising from the chemical
Special Hazards of Combustion Products: Toxic oxides of nitrogen may form in fires. Behavior in Fire: Heat exposure may cause pressure build-up
in closed containers. (USCG, 1999)
5.3 Special protective actions for fire-fighters
Wear self-contained breathing apparatus for firefighting if necessary.
6.Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel
to safe areas. Avoid breathing dust. For personal protection see section 8.
6.2 Environmental precautions
Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Do NOT let this
chemical enter the environment. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert
absorbent. Then store and dispose of according to local regulations.
6.3 Methods and materials for containment and cleaning up
Spread over with the 9:1 mixture of sand and soda ash. After mixing, transfer into a paper carton, stuffed with ruffled paper.
7.Handling and storage
7.1 Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide
appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Provision to contain effluent from fire extinguishing. Separated from strong oxidants, acids, acid anhydrides and food and feedstuffs. Dry. Keep in
the dark. Well closed. Store in an area without drain or sewer access.PROTECT FROM LIGHT & MOISTURE.
8.Exposure controls/personal protection
8.1 Control parameters
Occupational Exposure limit values
no data available
Biological limit values
no data available
8.2 Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
8.3 Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection
Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government
standards such as NIOSH (US) or EN 166(EU).
Skin protection
Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous
substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without
touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable
laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive
89/686/EEC and the standard EN 374 derived from it.
Respiratory protection
Wear dust mask when handling large quantities.
Thermal hazards
no data available
9.Physical and chemical properties
Physical state colourless to brown liquid
Colour COLORLESS TO BROWN /SRP: TECHNICAL GRADE/
Odour Penetrating odor, not as offensive as pyridine
Melting point/ freezing point -15°C(lit.)
Boiling point or initial boiling point and boiling range 113-114°C/11mmHg(lit.)
Flammability Combustible. Gives off irritating or toxic fumes (or gases) in a fire.
Lower and upper explosion limit / flammability limit no data available
Flash point 101°C
Auto-ignition temperature 480°C
Decomposition temperature no data available
pH Weak tertiary base
Kinematic viscosity 2.997 millipascal second (=cP) at 30°C
Solubility In water:slightly soluble
Partition coefficient n-octanol/water (log value) log Kow= 2.03
Vapour pressure 0.07 mm Hg ( 20 °C)
Density and/or relative density 1.093g/mLat 25°C(lit.)
Relative vapour density 4.5 (vs air)
Particle characteristics no data available
10.Stability and reactivity
10.1 Reactivity
no data available
10.2 Chemical stability
DARKENS ON STORAGE IN ORDINARY, STOPPERED BOTTLE
10.3 Possibility of hazardous reactions
IT IS MODERATELY FLAMMABLE BUT DOES NOT EVOLVE A FLAMMABLE CONCN OF VAPOR AT TEMP OF BELOW 99
DEG C.QUINOLINE is hygroscopic. It absorbs as much as 22% water. It is sensitive to light and moisture. It darkens on storage. This chemical
is a weak base. A potentially explosive reaction may occur with hydrogen peroxide. It reacts violently with dinitrogen tetraoxide. It also reacts
violently with perchromates. It is incompatible with (linseed oil + thionyl chloride) and maleic anhydride. It is also incompatible with strong oxidizers
and strong acids. This chemical can be unpredictably violent. It dissolves sulfur, phosphorus and arsenic trioxide. It may attack some forms of
plastics. It is a preparative hazard.
10.4 Conditions to avoid
no data available
10.5 Incompatible materials
VIOLENT REACTION WITH DINITROGEN TETRAOXIDE; PERCHROMATES.
10.6 Hazardous decomposition products
When heated to decomposition it emits toxic fumes of /nitrogen oxides/.
11.Toxicological information
Acute toxicity
Oral: LD50 Rat oral 460 mg/kg
Inhalation: no data available
Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
no data available
Reproductive toxicity
No information is available on the reproductive or developmental effects of quinoline in humans or animals.
STOT-single exposure
no data available
STOT-repeated exposure
no data available
Aspiration hazard
no data available
12.Ecological information
12.1 Toxicity
Toxicity to fish: no data available
Toxicity to daphnia and other aquatic invertebrates: no data available
Toxicity to algae: no data available
Toxicity to microorganisms: no data available
12.2 Persistence and degradability
With 9 natural water samples, 1 ppm quinoline had 3-10 day lag then 100% degradation in 24-48 hr; 1 ppm redose had 2-4 hr lag then 100%
degradation in 24-48 hr(1). Using a 9 L aerated fermentor with 3 natural water samples and 1 sewage plant aeration effluent spiked with 10 ug/ml
quinoline, an adaptation period was observed and greater than or equal to 95% biodegradation in 48 hr (25°C), 60 hr (25°C), 11 days (15°C)
and 60 hours (25°C), respectively(2). Batch fermentations using low level inocula from a eutrophic pond initially spiked with 1,3,5 and 10 ug/ml
quinoline resulted in 100% biodegradation in <16 hr(2). Major metabolites expected: 2-hydroxyquinoline, 2,3-dihydroxyquinoline(2). 66%
theoretical BOD (TBOD) was observed after 5 days with the standard dilution method and sewage as seed(4). Using 100 ppm quinoline and 30
ppm activated sludge, < 30% TBOD was observed in 2 weeks(5). With 10 ug/ml quinoline with pond water in 9 l bottle, approximately 2 day lag
period followed by 100% biodegradation in < 24 hr; four subsequent redoses in shaker flasks with 0.2% v/v (NH4)2SO4 - potassium phosphate
buffer resulted in 100% biodegradation in less than or equal to 24 hours(3). Bacterium isolated from soil used quinoline as sole carbon during
aerobic degradation(6). Quinoline was degraded to 2-hydroxyquinoline by soil Pseudomonads in enrichment cultures isolated from a creosote-
contaminated site in Pensacola, FL(7).
12.3 Bioaccumulative potential
At an initial concentration of 0.8 and 0.08 mg/l, quinoline had a BCF ranging from <0.1-2.5 and <1.0-3.8, respectively, in orange red killifish(1).
Rainbow trout swimup fry, ranging from 0.21-0.41 g in size, were exposed to quinoline at 1 mg/l for 48 hours and analyzed for
bioconcentration(2). Whole body levels of quinoline increased rapidly during the first 4 hours of exposure and reached an apparent plateau after
about 24 hours. Quinoline had a calculated bioconcentration factor of 3.73. After 48 hours, the fish were placed in non-quinoline contaminated
water for 24 hours and monitored for depuration(2). Less than 2% of unmetabolized quinoline remained after the 24-hour depuration period.
Metabolites found within fish tissues included hydroxyquinolines and quinolinethiols(2). In a static exposure study using fathead minnows,
Pimephales promelas, a bioconcentration factor (BCF) of 8 was measured(3). According to a classification scheme(4), these BCF values suggest
the potential for bioconcentration in aquatic organisms is low(SRC).
12.4 Mobility in soil
The measured log Koc for quinoline is 2.84(1). The adsorption coefficients of quinoline to Ca-montmorillonite and creek sediments are 7.3 and
10.9, respectively(2). A Koc of 43 was reported using low-organic-carbon subsurface materials(11). According to a classification scheme(3),
these Koc values suggest that quinoline is expected to have very high mobility in soil. Quinoline was found to be relatively mobile using a Danish
sandy soil(10). Intensity of quinoline added to a natural sand aquifer on the Canadian Air Force Base Borden, Ontario, Canada via a field study
using coal tar creosote were found to increase after 278 days, about 25 m from the croesote source, added at an initial concn of 10.1 g/kg
creosote(4). Aromatic amines are expected to bind strongly to humus or organic matter in soils due to the high reactivity of the aromatic amino
group(7,8), suggesting that mobility may be much lower in some soils(SRC). The pKa of quinoline is 4.90(5), indicating that this compound will
partially exist in the protonated form in the environment and cations generally adsorb to organic carbon and clay more strongly than their neutral
counterparts(6); therefore, adsorption increases with increasing soil acidity(11). Sorption onto airborne particulates has been observed(9). A Kd
value of 0.83 was measured using a Danish sandy soil from Lundgaard, Jutland, characterized by 2.47% organic carbon content, 80.2% sand,
13.2% silt, 4.8% clay, and a pH of 5.8(10).
12.5 Other adverse effects
no data available
13.Disposal considerations
13.1 Disposal methods
Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not
contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it
unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible
packaging materials.
14.Transport information
14.1 UN Number
ADR/RID: UN2656IMDG: UN2656IATA: UN2656
14.2 UN Proper Shipping Name
ADR/RID: QUINOLINE
IMDG: QUINOLINE
IATA: QUINOLINE
14.3 Transport hazard class(es)
ADR/RID: 6.1IMDG: 6.1IATA: 6.1
14.4 Packing group, if applicable
ADR/RID: IIIIMDG: IIIIATA: III
14.5 Environmental hazards
ADR/RID: yesIMDG: yesIATA: yes
14.6 Special precautions for user
no data available
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
no data available
15.Regulatory information
15.1 Safety, health and environmental regulations specific for the product in question
Chemical name Common names and synonyms CAS number EC number
quinoline quinoline 91-22-5 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Not Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC)Listed.
16.Other information
Information on revision
Creation Date Aug 12, 2017
Revision Date Aug 12, 2017
Abbreviations and acronyms
CAS: Chemical Abstracts Service
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
IMDG: International Maritime Dangerous Goods
IATA: International Air Transportation Association
TWA: Time Weighted Average
STEL: Short term exposure limit
LC50: Lethal Concentration 50%
LD50: Lethal Dose 50%
EC50: Effective Concentration 50%
References
IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website:
http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this
document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any
guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.