SAFETY DATA SHEETS
According to Globally Harmonized System of Classification and Labelling of
Chemicals (GHS) - Sixth revised edition
Version: 1.0
Creation Date: Aug 10, 2017
Revision Date: Aug 10, 2017
1.Identification
1.1 GHS Product identifier
Product name hydroquinone
1.2 Other means of identification
Product number-
Other names 1,4-benzenediol
1.3 Recommended use of the chemical and restrictions on use
Identified
uses
For industry use only. Hydroquinone is used as a developing agent in black-and-white photography, lithography, and x-ray films. It is
also used as an intermediate to produce antioxidants for rubber and food. It is added to a number of industrial monomers to inhibit
polymerization during shipping, storage, and processing.
Uses
advised
against
no data available
1.4 Supplier's details
1.5 Emergency phone number
Emergency phone number-
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).
2.Hazard identification
2.1 Classification of the substance or mixture
Acute toxicity - Oral, Category 4
Serious eye damage, Category 1
Skin sensitization, Category 1
Germ cell mutagenicity, Category 2
Carcinogenicity, Category 2
Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1
2.2 GHS label elements, including precautionary statements
Pictogram(s)
Danger
Signal word
Danger
Hazard statement(s)
H302 Harmful if swallowed
H318 Causes serious eye damage
H317 May cause an allergic skin reaction
H341 Suspected of causing genetic defects
H351 Suspected of causing cancer
H400 Very toxic to aquatic life
Precautionary
statement(s)
Prevention
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P272 Contaminated work clothing should not be allowed out of the workplace.
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P273 Avoid release to the environment.
Response
P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/…if you feel unwell.
P330 Rinse mouth.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and
easy to do. Continue rinsing.
P310 Immediately call a POISON CENTER/doctor/…
P302+P352 IF ON SKIN: Wash with plenty of water/...
P333+P313 If skin irritation or rash occurs: Get medical advice/attention.
P321 Specific treatment (see ... on this label).
P362+P364 Take off contaminated clothing and wash it before reuse.
P308+P313 IF exposed or concerned: Get medical advice/ attention.
P391 Collect spillage.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to ...
2.3 Other hazards which do not result in classification
none
3.Composition/information on ingredients
3.1 Substances
Chemical name Common names and synonyms CAS numberEC numberConcentration
hydroquinone hydroquinone 123-31-9 none 100%
4.First-aid measures
4.1 Description of necessary first-aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.
In case of skin contact
Remove contaminated clothes. Rinse and then wash skin with water and soap.
In case of eye contact
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
If swallowed
Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention .
4.2 Most important symptoms/effects, acute and delayed
This material is very toxic; the probable oral lethal dose for humans is 50-500 mg/kg, or between 1 teaspoon and 1 ounce for a 150 lb. person. It
is irritating but not corrosive. Fatal human doses have ranged from 5-12 grams, but 300-500 mg have been ingested daily for 3-5 months without
ill effects. Death is apparently initiated by respiratory failure or anoxia. (EPA, 1998)
4.3 Indication of immediate medical attention and special treatment needed, if necessary
/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration,
preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush
contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down
position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical
attention. /Aniline and related compounds/
5.Fire-fighting measures
5.1 Extinguishing media
Suitable extinguishing media
To fight fire, use water, carbon dioxide, dry chem ... .
5.2 Specific hazards arising from the chemical
Dust cloud may explode if ignited in an enclosed area. It can react with oxidizing materials and is rapidly oxidized in the presence of alkaline
materials. Oxidizes in air. (EPA, 1998)
5.3 Special protective actions for fire-fighters
Wear self-contained breathing apparatus for firefighting if necessary.
6.Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel
to safe areas. Avoid breathing dust. For personal protection see section 8.
6.2 Environmental precautions
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the
environment. Sweep spilled substance into covered sealable containers. Carefully collect remainder. Then store and dispose of according to local
regulations.
6.3 Methods and materials for containment and cleaning up
Environmental Considerations: Land spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material. Cover solids with a plastic sheet
to prevent dissolving in rain or fire fighting water. Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk
liquid with fly ash, cement powder, or commercial sorbents. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be
sealed with an impermeable flexible membrane liner./
7.Handling and storage
7.1 Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide
appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Separated from strong bases and food and feedstuffs.Keep well closed and protected from light.
8.Exposure controls/personal protection
8.1 Control parameters
Occupational Exposure limit values
Recommended Exposure Limit: 15 Min Ceiling Value: 2 mg/cu m.
Biological limit values
no data available
8.2 Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
8.3 Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection
Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government
standards such as NIOSH (US) or EN 166(EU).
Skin protection
Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous
substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without
touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable
laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive
89/686/EEC and the standard EN 374 derived from it.
Respiratory protection
Wear dust mask when handling large quantities.
Thermal hazards
no data available
9.Physical and chemical properties
Physical state off-white powder or white needle-like crystals
Colour White crystals
Odour Odorless
Melting point/ freezing point 2°C(lit.)
Boiling point or initial boiling point and boiling range 285°C(lit.)
Flammability Combustible Solid; dust cloud may explode if ignited in an enclosed area.Combustible.
Lower and upper explosion limit / flammability limit no data available
Flash point 165°C
Auto-ignition temperature 498.89°C
Decomposition temperature no data available
pH no data available
Kinematic viscosity no data available
Solubility In water:70 g/L (20 oC)
Partition coefficient n-octanol/water (log value) no data available
Vapour pressure 1 mm Hg ( 132 °C)
Density and/or relative density 1.332
Relative vapour density 3.81 (vs air)
Particle characteristics no data available
10.Stability and reactivity
10.1 Reactivity
no data available
10.2 Chemical stability
Its solution becomes brown in air due to oxidation.
10.3 Possibility of hazardous reactions
Fire hazard: slight, when exposed to heat or flame; can react with oxidizing materials.Dust explosion possible if in powder or granular form, mixed
with air.HYDROQUINONE is a slight explosion hazard when exposed to heat. Incompatible with strong oxidizing agents. Also incompatible with
bases. It reacts with oxygen and sodium hydroxide. Reacts with ferric salts . Hot and/or concentrated NaOH can cause hydroquinone to
decompose exothermically at elevated temperature. (NFPA Pub. 491M, 1975, 385)
10.4 Conditions to avoid
no data available
10.5 Incompatible materials
Strong oxidizers, alkalis.
10.6 Hazardous decomposition products
no data available
11.Toxicological information
Acute toxicity
Oral: LD50 Rat oral 320 mg/kg
Inhalation: no data available
Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
Evaluation: There is inadequate evidence in humans for the carcinogenicity of hydroquinone. There is limited evidence in experimental animals for
the carcinogenicity of hydroquinone. Overall evaluation: Hydroquinone is not classifiable as to its carcinogenicity to humans (Group 3).
Reproductive toxicity
No information is available on the reproductive or developmental effects of hydroquinone in humans. A slight reduction in maternal body weight
gain, decreased fetal weight, increased resorption rate, and reduced fertility in males have been observed in rats orally exposed to hydroquinone
via gavage or in the diet. Exposure of rabbits to hydroquinone via gavage produced negligible developmental alterations.
STOT-single exposure
no data available
STOT-repeated exposure
no data available
Aspiration hazard
no data available
12.Ecological information
12.1 Toxicity
Toxicity to fish: LC50; Species: Danio rerio (Zebra danio) length 2.5 cm; Conditions: freshwater, static, 22°C, pH 7-7.8, hardness 150
mg/L CaCO3; Concentration: <1000 ug/L for 24 hr
Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water flea) age 6-24 hr; Conditions: freshwater, static,
20°C, pH > or =7.0; Concentration: 320 ug/L for 24 hr (95% confidence interval: 270-380 ug/L); Effect: intoxication, immobilization
/formulation
Toxicity to algae: no data available
Toxicity to microorganisms: no data available
12.2 Persistence and degradability
AEROBIC: Hydroquinone at a concentration of 0.05 mg/L underwent 7.5% removal in 5 days when inoculated with an activated sludge
seed(1,2). Sewage sludge activated to phenol was found to oxidize hydroquinone(3,4). Pure culture oxidation of hydroquinone produced 1,4-
benzoquinone, 2-hydroxy-1,4-benzoquinone and beta-ketoadipic acid(5). In a screening study using a sewage seed, hydroquinone had a 5 day
theoretical BOD of 25.3%(6). Hydroquinone at an initial concentration of 200 mg/L COD underwent 54.2% removal (less than 120 hours) using a
thickened adapted activated sludge under aerobic conditions(7). Activated sludges adapted to aniline, phenol or m-cresol were found to
biodegrade hydroquinone under aerobic conditions(8). It was listed as undergoing rapid biodegradation in a commercial activated sludge unit
under aerobic conditions(9).
12.3 Bioaccumulative potential
An estimated BCF of 3 was calculated in fish for hydroquinone(SRC), using a log Kow of 0.59(1) and a regression-derived equation(2).
According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). A bioaccumulation
factor of 40 was measured using Golden ide fish (Leuciscus idus melanotus) exposed for 3 days to 0.05 mg/L hydroquinone(4,5). Experimental
24-hour bioaccumulation factors in alga were 40 and 65 for hydroquinone(4-6).
12.4 Mobility in soil
Using a structure estimation method based on molecular connectivity indices(1), the Koc of hydroquinone is estimated as 240(SRC). According to
a classification scheme(2), this estimated Koc value suggests that hydroquinone is expected to have moderate mobility in soil. Hydroquinone can
exhibit chemisorption to transition metal-containing particulate matter via reaction with the copper oxide/silca surfaces present(3).
12.5 Other adverse effects
no data available
13.Disposal considerations
13.1 Disposal methods
Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not
contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it
unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible
packaging materials.
14.Transport information
14.1 UN Number
ADR/RID: UN3077IMDG: UN3077IATA: UN3077
14.2 UN Proper Shipping Name
ADR/RID: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S.
IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S.
IATA: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S.
14.3 Transport hazard class(es)
ADR/RID: 9IMDG: 9IATA: 9
14.4 Packing group, if applicable
ADR/RID: IIIIMDG: IIIIATA: III
14.5 Environmental hazards
ADR/RID: yesIMDG: yesIATA: yes
14.6 Special precautions for user
no data available
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
no data available
15.Regulatory information
15.1 Safety, health and environmental regulations specific for the product in question
Chemical name Common names and synonyms CAS number EC number
hydroquinone hydroquinone 123-31-9 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC)Listed.
16.Other information
Information on revision
Creation Date Aug 10, 2017
Revision Date Aug 10, 2017
Abbreviations and acronyms
CAS: Chemical Abstracts Service
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
IMDG: International Maritime Dangerous Goods
IATA: International Air Transportation Association
TWA: Time Weighted Average
STEL: Short term exposure limit
LC50: Lethal Concentration 50%
LD50: Lethal Dose 50%
EC50: Effective Concentration 50%
References
IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website:
http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this
document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any
guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product