SAFETY DATA SHEETS
According to Globally Harmonized System of Classification and Labelling of
Chemicals (GHS) - Sixth revised edition
Version: 1.0
Creation Date: Aug 11, 2017
Revision Date: Aug 11, 2017
1.Identification
1.1 GHS Product identifier
Product name aldehydo-D-glucose
1.2 Other means of identification
Product number -
Other names D-(+)-Glucose
1.3 Recommended use of the chemical and restrictions on use
Identified uses For industry use only. Processing Aids and Additives
Uses advised against no data available
1.4 Supplier's details
1.5 Emergency phone number
Emergency phone number -
Service hours Monday to Friday, 9am-5pm(Standard time zone: UTC/GMT +8 hours).
2.Hazard identification
2.1 Classification of the substance or mixture
Not classified.
2.2 GHS label elements, including precautionary statements
Pictogram(s) No symbol.
Signal word No signal word.
Hazard statement(s) none
Precautionary statement(s)
Prevention none
Response none
Storage none
Disposal none
2.3 Other hazards which do not result in classification
none
3.Composition/information on ingredients
3.1 Substances
Chemical name Common names and synonyms CAS number EC number Concentration
aldehydo-D-glucose aldehydo-D-glucose 50-99-7 none 100%
4.First-aid measures
4.1 Description of necessary first-aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
Fresh air, rest.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
If swallowed
Rinse mouth.
4.2 Most important symptoms/effects, acute and delayed
No toxicity (USCG, 1999)
4.3 Indication of immediate medical attention and special treatment needed, if necessary
Pancreatic beta cells are highly sensitive to oxidative stress, which might play an important role in beta cell death in diabetes. The protective effect
of 6,6'-bieckol, a phlorotannin polyphenol compound purified fromEcklonia cava, against high glucose-induced glucotoxicity was investigated in
rat insulinoma cells. High glucose (30 mM) treatment induced the death of rat insulinoma cells, but treatment with 10 or 50 ug/mL 6,6'-bieckol
significantly inhibited the high glucose-induced glucotoxicity. Furthermore, treatment with 6,6'-bieckol dose-dependently reduced the level of
thiobarbituric acid reactive substances, generation of intracellular reactive oxygen species, and the level of nitric oxide, all of which were increased
by high glucose concentration. In addition, 6,6'-bieckol protected rat insulinoma cells fromapoptosis under high-glucose conditions. These effects
were associated with increased expression of the anti-apoptotic protein Bcl-2 and reduced expression of the pro-apoptotic protein Bax. These
findings indicate that 6,6'-bieckol could be used as a potential nutraceutical agent offering protection against the glucotoxicity caused by
hyperglycemia-induced oxidative stress associated with diabetes.
5.Fire-fighting measures
5.1 Extinguishing media
Suitable extinguishing media
Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
5.2 Specific hazards arising from the chemical
no data available
5.3 Special protective actions for fire-fighters
Wear self-contained breathing apparatus for firefighting if necessary.
6.Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel
to safe areas. Avoid breathing dust. For personal protection see section 8.
6.2 Environmental precautions
Sweep spilled substance into covered containers. Wash away remainder with plenty of water.
6.3 Methods and materials for containment and cleaning up
ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Avoid dust formation. Avoid
breathing vapors, mist or gas; Environmental precautions: No special environmental precautions required; Methods and materials for containment
and cleaning up: Sweep up and shovel. Keep in suitable, closed containers for disposal.
7.Handling and storage
7.1 Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide
appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Separated fromstrong oxidants. Well closed.Keep container tightly closed in a dry and well-ventilated place. Hygroscopic. Keep in a dry place.
8.Exposure controls/personal protection
8.1 Control parameters
Occupational Exposure limit values
no data available
Biological limit values
no data available
8.2 Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
8.3 Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection
Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government
standards such as NIOSH (US) or EN 166(EU).
Skin protection
Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous
substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without
touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable
laws
and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive
89/686/EEC and the standard EN 374 derived fromit.
Respiratory protection
Wear dust mask when handling large quantities.
Thermal hazards
no data available
9.Physical and chemical properties
Physical state White crystalline powder
Colour Colorless crystals or white granular powder
Odour Odorless
Melting point/ freezing point 9°C(lit.)
Boiling point or initial boiling point and boiling
range
73°C/25mmHg(lit.)
Flammability Combustible.
Lower and upper explosion limit / flammability limit no data available
Flash point 40°C(lit.)
Auto-ignition temperature Not flammable (USCG, 1999)
Decomposition temperature no data available
pH pH of 0.5 molar aqueous solution = 5.9 /alpha-glucose/
Kinematic viscosity no data available
Solubility In water:Soluble
Partition coefficient n-octanol/water (log value) no data available
Vapour pressure 8.0X10-14 mmHg at 25°C /extrapolated froma higher solid-phase temperature range/
Density and/or relative density 1.544g/cm3
Relative vapour density no data available
Particle characteristics no data available
10.Stability and reactivity
10.1 Reactivity
no data available
10.2 Chemical stability
Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions
Dust explosion possible if in powder or granular form, mixed with air.A weak reducing agent.
10.4 Conditions to avoid
no data available
10.5 Incompatible materials
Incompatible materials: Strong oxidizing agents
10.6 Hazardous decomposition products
When heated to decomposition it emits acrid smoke and irritating fumes.
11.Toxicological information
Acute toxicity
Oral: LD50 Rat oral 25,800 mg/kg
Inhalation: no data available
Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germcell mutagenicity
no data available
Carcinogenicity
no data available
Reproductive toxicity
no data available
STOT-single exposure
no data available
STOT-repeated exposure
no data available
Aspiration hazard
no data available
12.Ecological information
12.1 Toxicity
Toxicity to fish: no data available
Toxicity to daphnia and other aquatic invertebrates: no data available
Toxicity to algae: no data available
Toxicity to microorganisms: no data available
12.2 Persistence and degradability
AEROBIC: D(+)-Glucose, present at 1000 mg/L, reached >90% of its theoretical BOD in 2 days using a non-adapted activated sludge inoculum
at 1 g/L (dry matter) in a Zahn-Wellens static test(1). The biodegradation half-life of D(+)-glucose in aerobic aquifer material (not heavily
polluted), including Ontario loamand sand, South Carolina sand and Holland sand, is reported to range from0.6-1.1 days(2). Using an electrolytic
respirometry method with a 100 mg/L compound concentration and an activated sludge inoculum, D(+)-glucose was easily biodegraded with a
46-56% theoretical BOD in 100-110 hours(3). Using standard and seawater dilution methods, the 5-day BOD of D(+)-glucose was determined
as 74.8 and 75.2% respectively(4). D(+)-Glucose was readily biodegradable in batch tests using adapted activated sludge with a biodegradation
rate of 180.0 mg COD/g-hour(5). Biodegradation of D(+)-glucose in various samples of aquifer, saturated zone, and surface soils was found to
occur rapidly with somewhat slower rates in till soil samples(6); based on measured rate constants(6), the biodegradation half-life ranged from
0.25 to 19 days.
12.3 Bioaccumulative potential
An estimated BCF of 3 was calculated in fish for D(+)-glucose(SRC), using a log Kow of -3.00(1) and a regression-derived equation(2).
According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
12.4 Mobility in soil
Using a structure estimation method based on molecular connectivity indices(1), the Koc of D(+)-glucose can be estimated to be 10(SRC).
According to a classification scheme(2), this estimated Koc value suggests that D(+)-glucose is expected to have very high mobility in soil.
12.5 Other adverse effects
no data available
13.Disposal considerations
13.1 Disposal methods
Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not
contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it
unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible
packaging materials.
14.Transport information
14.1 UN Number
ADR/RID: Not dangerous goods. IMDG: Not dangerous goods. IATA: Not dangerous goods.
14.2 UN Proper Shipping Name
ADR/RID: unknown
IMDG: unknown
IATA: unknown
14.3 Transport hazard class(es)
ADR/RID: Not dangerous goods. IMDG: Not dangerous goods. IATA: Not dangerous goods.
14.4 Packing group, if applicable
ADR/RID: Not dangerous goods. IMDG: Not dangerous goods. IATA: Not dangerous goods.
14.5 Environmental hazards
ADR/RID: no IMDG: no IATA: no
14.6 Special precautions for user
no data available
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
no data available
15.Regulatory information
15.1 Safety, health and environmental regulations specific for the product in question
Chemical name Common names and synonyms CAS number EC number
aldehydo-D-glucose aldehydo-D-glucose 50-99-7 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Not Listed.
NewZealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
VietnamNational Chemical Inventory Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.
16.Other information
Information on revision
Creation Date Aug 11, 2017
Revision Date Aug 11, 2017
Abbreviations and acronyms
CAS: Chemical Abstracts Service
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
IMDG: International Maritime Dangerous Goods
IATA: International Air Transportation Association
TWA: Time Weighted Average
STEL: Short termexposure limit
LC50: Lethal Concentration 50%
LD50: Lethal Dose 50%
EC50: Effective Concentration 50%
References
IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website:
http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Disclaimer: The above information is believedto be correct but does not purport to be all inclusive andshall be usedonly as a guide. The information in this
document is basedon the present state of our knowledge andis applicable to the product with regardto appropriate safety precautions. It does not represent any
guarantee of the properties of the product. We as supplier shall not be heldliable for any damage resulting from handling or from co