SAFETY DATA SHEETS
According to Globally Harmonized System of Classification and Labelling of
Chemicals (GHS) - Sixth revised edition
Version: 1.0
Creation Date: Aug 10, 2017
Revision Date: Aug 10, 2017
1.Identification
1.1 GHS Product identifier
Product name adipic acid
1.2 Other means of identification
Product number-
Other names Hexanedioic acid
1.3 Recommended use of the chemical and restrictions on use
Identified uses For industry use only. Processing Aids and Additives
Uses advised againstno data available
1.4 Supplier's details
1.5 Emergency phone number
Emergency phone number-
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).
2.Hazard identification
2.1 Classification of the substance or mixture
Eye irritation, Category 2
2.2 GHS label elements, including precautionary statements
Pictogram(s)
Signal word Warning
Hazard statement(s) H319 Causes serious eye irritation
Precautionary
statement(s)
Prevention
P264 Wash ... thoroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
Response
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and
easy to do. Continue rinsing.
P337+P313 If eye irritation persists: Get medical advice/attention.
Storage none
Disposal
none
2.3 Other hazards which do not result in classification
none
3.Composition/information on ingredients
3.1 Substances
Chemical name Common names and synonyms CAS numberEC numberConcentration
adipic acid adipic acid 124-04-9 none 100%
4.First-aid measures
4.1 Description of necessary first-aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
Fresh air, rest. Refer for medical attention.
In case of skin contact
Remove contaminated clothes. Rinse skin with plenty of water or shower.
In case of eye contact
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
If swallowed
Rinse mouth. Rest. Refer for medical attention .
4.2 Most important symptoms/effects, acute and delayed
Inhalation of vapor irritates mucous membranes of the nose and lungs, causing coughing and sneezing. Contact with liquid irritates eyes and has a
pronounced drying effect on the skin; may produce dermatitis. (USCG, 1999)
4.3 Indication of immediate medical attention and special treatment needed, if necessary
Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with
a demand-valve resuscitator, bag-valve-mask device, or pocket mask as trained. Perform CPR if necessary. Immediately flush contaminated eyes
with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to
maintain an open airway and prevent aspiration. Keep victim quiet and maintain normal body temperature. Obtain medical attention. /Organic acids
and related compounds/
5.Fire-fighting measures
5.1 Extinguishing media
Suitable extinguishing media
Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
5.2 Specific hazards arising from the chemical
Behavior in Fire: Melts and may decompose to give volatile acidic vapors of valeric acid and other substances. Dust may form explosive mixture
with air. (USCG, 1999)
5.3 Special protective actions for fire-fighters
Wear self-contained breathing apparatus for firefighting if necessary.
6.Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel
to safe areas. Avoid breathing dust. For personal protection see section 8.
6.2 Environmental precautions
Sweep spilled substance into covered plastic containers. If appropriate, moisten first to prevent dusting. Wash away remainder with plenty of
water.
6.3 Methods and materials for containment and cleaning up
Accidental release measures. Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid
dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust.;
Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must
be avoided.; Methods and materials for containment and cleaning up: Pick up and arrange disposal without creating dust. Sweep up and shovel.
Keep in suitable, closed containers for disposal.
7.Handling and storage
7.1 Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide
appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Conditions for safe storage, including any incompatibilities: Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS
510): Non Combustible Solids.
8.Exposure controls/personal protection
8.1 Control parameters
Occupational Exposure limit values
no data available
Biological limit values
no data available
8.2 Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
8.3 Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection
Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government
standards such as NIOSH (US) or EN 166(EU).
Skin protection
Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous
substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without
touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable
laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive
89/686/EEC and the standard EN 374 derived from it.
Respiratory protection
Wear dust mask when handling large quantities.
Thermal hazards
no data available
9.Physical and chemical properties
Physical state White crystalline powder.
Colour Monoclinic prisms from ethyl acetate, water, or acetone and petroleum ether
Odour Odorless
Melting point/ freezing point 139°C(lit.)
Boiling point or initial boiling point and boiling range 186°C
Flammability Combustible.
Lower and upper explosion limit / flammability limit In air: (dust) 10-15 mg/l
Flash point 80°C(lit.)
Auto-ignition temperature 420°C; 232.22°C (USCG, 1999)
Decomposition temperature no data available
pH pH of saturated aqueous solution at 25°C = 2.7; pH of 0.1% solution at 25°C = 3.2
Kinematic viscosity Viscosity of melt: 4.54 cP at 160°C; 2.64 cP at 193°C
Solubility In water:1.44 g/100 mL (15 oC)
Partition coefficient n-octanol/water (log value) log Kow = 0.08
Vapour pressure 1 mm Hg ( 159.5 °C)
Density and/or relative density 1.36 g/cm3
Relative vapour density 5 (vs air)
Particle characteristics no data available
10.Stability and reactivity
10.1 Reactivity
no data available
10.2 Chemical stability
Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions
Combustible when exposed to heat or flame ...Dust explosion possible if in powder or granular form, mixed with air. If dry, it can be charged
electrostatically by swirling, pneumatic transport, pouring, etc.ADIPIC ACID is a carboxylic acid. Carboxylic acids donate hydrogen ions if a base
is present to accept them. They react in this way with all bases, both organic (for example, the amines) and inorganic. Their reactions with bases,
called "neutralizations", are accompanied by the evolution of substantial amounts of heat. Neutralization between an acid and a base produces
water plus a salt. Carboxylic acids with six or fewer carbon atoms are freely or moderately soluble in water; those with more than six carbons are
slightly soluble in water. Soluble carboxylic acid dissociate to an extent in water to yield hydrogen ions. The pH of solutions of carboxylic acids is
therefore less than 7.0. Many insoluble carboxylic acids react rapidly with aqueous solutions containing a chemical base and dissolve as the
neutralization generates a soluble salt. Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to
form gaseous hydrogen and a metal salt. Such reactions occur in principle for solid carboxylic acids as well, but are slow if the solid acid remains
dry. Even "insoluble" carboxylic acids may absorb enough water from the air and dissolve sufficiently in it to corrode or dissolve iron, steel, and
aluminum parts and containers. Carboxylic acids, like other acids, react with cyanide salts to generate gaseous hydrogen cyanide. The reaction is
slower for dry, solid carboxylic acids. Insoluble carboxylic acids react with solutions of cyanides to cause the release of gaseous hydrogen cyanide.
Flammable and/or toxic gases and heat are generated by the reaction of carboxylic acids with diazo compounds, dithiocarbamates, isocyanates,
mercaptans, nitrides, and sulfides. Carboxylic acids, especially in aqueous solution, also react with sulfites, nitrites, thiosulfates (to give H2S and
SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Their reaction with carbonates and bicarbonates generates a harmless
gas (carbon dioxide) but still heat. Like other organic compounds, carboxylic acids can be oxidized by strong oxidizing agents and reduced by
strong reducing agents. These reactions generate heat. A wide variety of products is possible. Like other acids, carboxylic acids may initiate
polymerization reactions; like other acids, they often catalyze (increase the rate of) chemical reactions. Behavior in Fire: Melts and may decompose
to give volatile acidic vapors of valeric acid and other substances.
10.4 Conditions to avoid
no data available
10.5 Incompatible materials
Incompatible materials: Strong oxidizing agents.
10.6 Hazardous decomposition products
Melts and may decompose to give volatile acidic vapors of valeric acid and other substances.
11.Toxicological information
Acute toxicity
Oral: LD50 Mouse oral 1900 mg/kg /From table/
Inhalation: Rat: inhalation: no effect level: 126 g/L, 15 x 6 hr (as in source)
Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
no data available
Reproductive toxicity
no data available
STOT-single exposure
no data available
STOT-repeated exposure
no data available
Aspiration hazard
no data available
12.Ecological information
12.1 Toxicity
Toxicity to fish: LC50; Species: Pimephales promelas (fathead minnow); Conditions: /static bioassay/; Concentration: >300 mg/L for 1 hr
Toxicity to daphnia and other aquatic invertebrates: no data available
Toxicity to algae: no data available
Toxicity to microorganisms: no data available
12.2 Persistence and degradability
AEROBIC: Results of biological screening tests indicate that adipic acid is readily biodegradable(1). Adipic acid, present at 100 mg/L, reached
81% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(2). In study with 10 participating
laboratories using OECD 301E (ready biodegradability test), all laboratories observed a ready biodegradability of adipic acid with a degradation
of at least 86% and an average degradation of 96.6% after 19 days(1). In an aerobic modified Sturm test (CO2 evolution) according to OECD
301B guideline, adipic acid was degraded by 91% in terms of CO2 evolution after a period of 28 days(1). In a closed bottle test (OECD 301D),
83% of the adipic acid was degraded after 30 days(1). In a test according to the modified OECD screening test (OECD 301E), 96% (related to
DOC) was degraded after a period of 19 days(1). In four biodegradability screening tests that were designed as models for degradability in
surface water, the results ranged from 92% of theoretical BOD in 14 days to 83% in 30 days(3,4). In 5 tests designed to simulate treatment plants,
results ranged from 99% DOC removal in 1 day to 92% of theoretical BOD in 14 days(3-5). In a systematic screening procedure after a 5-10 hr
lag, 50-75% of theoretical BOD of adipic acid was obtained in 90-100 hr(6). Adipic acid was rapidly degraded in a river die-away test using
Main River (Germany) water(5); 50% and 90% degradation being achieved in 3.5 and 7 days, respectively, at concentration levels of 700
mg/L(5). The Afnor test, which was designed to simulate degradation in polluted river water, gave a 5 day BOD of 36% of theoretical(7).
12.3 Bioaccumulative potential
An estimated BCF of 3 was calculated in fish for adipic acid(SRC), using a log Kow of 0.08(1) and a regression-derived equation(2). According
to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
12.4 Mobility in soil
Using a structure estimation method based on molecular connectivity indices(1), the Koc of adipic acid can be estimated to be 24(SRC).
According to a classification scheme(2), this estimated Koc value suggests that adipic acid is expected to have very high mobility in soil. The pKa
values of adipic acid's two acid groups are 4.44 and 5.44(3), indicating that this compound will exist almost entirely in the anion form and anions
generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4).
12.5 Other adverse effects
no data available
13.Disposal considerations
13.1 Disposal methods
Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not
contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it
unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible
packaging materials.
14.Transport information
14.1 UN Number
ADR/RID: UN1993IMDG: UN1993IATA: UN1993
14.2 UN Proper Shipping Name
ADR/RID: FLAMMABLE LIQUID, N.O.S.
IMDG: FLAMMABLE LIQUID, N.O.S.
IATA: FLAMMABLE LIQUID, N.O.S.
14.3 Transport hazard class(es)
ADR/RID: 3IMDG: 3IATA: 3
14.4 Packing group, if applicable
ADR/RID: IIIIMDG: IIIIATA: III
14.5 Environmental hazards
ADR/RID: noIMDG: noIATA: no
14.6 Special precautions for user
no data available
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
no data available
15.Regulatory information
15.1 Safety, health and environmental regulations specific for the product in question
Chemical name Common names and synonyms CAS number EC number
adipic acid adipic acid 124-04-9 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Not Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC)Listed.
16.Other information
Information on revision
Creation Date Aug 10, 2017
Revision Date Aug 10, 2017
Abbreviations and acronyms
CAS: Chemical Abstracts Service
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
IMDG: International Maritime Dangerous Goods
IATA: International Air Transportation Association
TWA: Time Weighted Average
STEL: Short term exposure limit
LC50: Lethal Concentration 50%
LD50: Lethal Dose 50%
EC50: Effective Concentration 50%
References
IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website:
http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this
document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any
guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.