SAFETY DATA SHEETS
According to Globally Harmonized System of Classification and Labelling of
Chemicals (GHS) - Sixth revised edition
Version: 1.0
Creation Date: Aug 12, 2017
Revision Date: Aug 12, 2017
1.Identification
1.1 GHS Product identifier
Product name 2,6-dimethylaniline
1.2 Other means of identification
Product number-
Other names o-Xylidine
1.3 Recommended use of the chemical and restrictions on use
Identified uses For industry use only.
Uses advised againstno data available
1.4 Supplier's details
1.5 Emergency phone number
Emergency phone number-
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).
2.Hazard identification
2.1 Classification of the substance or mixture
Acute toxicity - Oral, Category 4
Acute toxicity - Dermal, Category 4
Skin irritation, Category 2
Acute toxicity - Inhalation, Category 4
Specific target organ toxicity – single exposure, Category 3
Carcinogenicity, Category 2
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2
2.2 GHS label elements, including precautionary statements
Pictogram(s)
Signal word Warning
H302 Harmful if swallowed
Hazard statement(s)
H302 Harmful if swallowed
H312 Harmful in contact with skin
H315 Causes skin irritation
H332 Harmful if inhaled
H335 May cause respiratory irritation
H351 Suspected of causing cancer
H411 Toxic to aquatic life with long lasting effects
Precautionary statement(s)
Prevention
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P273 Avoid release to the environment.
Response
P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/…if you feel unwell.
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P312 Call a POISON CENTER/doctor/…if you feel unwell.
P321 Specific treatment (see ... on this label).
P362+P364 Take off contaminated clothing and wash it before reuse.
P332+P313 If skin irritation occurs: Get medical advice/attention.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P308+P313 IF exposed or concerned: Get medical advice/ attention.
P391 Collect spillage.
Storage
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
Disposal P501 Dispose of contents/container to ...
2.3 Other hazards which do not result in classification
none
3.Composition/information on ingredients
3.1 Substances
Chemical name Common names and synonyms CAS numberEC numberConcentration
2,6-dimethylaniline2,6-dimethylaniline 87-62-7 none 100%
4.First-aid measures
4.1 Description of necessary first-aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
Fresh air, rest. Refer for medical attention.
In case of skin contact
Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .
In case of eye contact
Rinse with plenty of water for several minutes (remove contact lenses if easily possible).
If swallowed
Rinse mouth. Refer for medical attention .
4.2 Most important symptoms/effects, acute and delayed
May be fatal if inhaled, swallowed or absorbed through skin. Vapor or mist irritating to the eyes, mucous membranes and upper respiratory tract;
causes skin irritation. Absorption into body leads to the formation of methemoglobin which, in sufficient concentration, may cause cyanosis. Onset
may be delayed 2-4 hours or longer. Exposure can cause nausea, dizziness, headache, damage to the eyes, and blood effects. (USCG, 1999)
4.3 Indication of immediate medical attention and special treatment needed, if necessary
Immediate First Aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably
with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated
eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if
possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention.
/Aromatic hydrocarbons and related compounds/
5.Fire-fighting measures
5.1 Extinguishing media
Suitable extinguishing media
Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide.
5.2 Specific hazards arising from the chemical
Special Hazards of Combustion Products: Container explosion may occur under fire conditions. Emits toxic fumes under fire conditions. (USCG,
1999)
5.3 Special protective actions for fire-fighters
Wear self-contained breathing apparatus for firefighting if necessary.
6.Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel
to safe areas. Avoid breathing dust. For personal protection see section 8.
6.2 Environmental precautions
Personal protection: chemical protection suit and filter respirator for organic gases and vapours adapted to the airborne concentration of the
substance. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb
remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
6.3 Methods and materials for containment and cleaning up
ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Use personal protective
equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas.
Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas. Environmental precautions: Prevent further
leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Methods and materials for
containment and cleaning up: Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in
container for disposal according to local regulations. Keep in suitable, closed containers for disposal.
7.Handling and storage
7.1 Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide
appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Separated from strong oxidants, acids, acid anhydrides, acid chlorides, hypochlorites, halogens and food and feedstuffs. Well closed. Store in an
area without drain or sewer access.Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully
resealed and kept upright to prevent leakage.
8.Exposure controls/personal protection
8.1 Control parameters
Occupational Exposure limit values
Recommended Exposure Limit: 10-hour Time-Weighted Average: 2 ppm (10 mg/cu m). Skin.
Biological limit values
no data available
8.2 Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
8.3 Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection
Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government
standards such as NIOSH (US) or EN 166(EU).
Skin protection
Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous
substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without
touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable
laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive
89/686/EEC and the standard EN 374 derived from it.
Respiratory protection
Wear dust mask when handling large quantities.
Thermal hazards
no data available
9.Physical and chemical properties
Physical state Colorless to reddish yellow liquid
Colour Yellow liquid
Odour Characteristic odor
Melting point/ freezing point 211°C(dec.)(lit.)
Boiling point or initial boiling point and boiling range 216°C(lit.)
Flammability Combustible. Gives off irritating or toxic fumes (or gases) in a fire.
Lower and upper explosion limit / flammability limit no data available
Flash point 91°C(lit.)
Auto-ignition temperature 405°C
Decomposition temperature no data available
pH no data available
Kinematic viscosity 1.7 mPa.s (dynamic) at 50°C
Solubility In water:7.5 g/L (20 oC)
Partition coefficient n-octanol/water (log value) log Kow = 1.84
Vapour pressure <0.01 mm Hg ( 20 °C)
Density and/or relative density 0.9842
Relative vapour density 4.17 (Relative to Air)
Particle characteristics no data available
10.Stability and reactivity
10.1 Reactivity
no data available
10.2 Chemical stability
Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions
This chemical is a combustible liquid. /Xylidines/The vapour is heavier than air.2,6-XYLIDINE reacts with strong oxidizing agents [Handling
Chemicals Safely 1980 p. 964]. Neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates,
halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in
combination with strong reducing agents, such as hydrides.
10.4 Conditions to avoid
no data available
10.5 Incompatible materials
Incompatible materials: Acids, acid chlorides, acid anhydrides, oxidizing agents, chloroformates, halogens.
10.6 Hazardous decomposition products
When heated to decomposition it emits toxic fumes of /nitrogen oxides/.
11.Toxicological information
Acute toxicity
Oral: LD50 Rat oral 840 mg/kg
Inhalation: no data available
Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
Evaluation: There is inadequate evidence in humans for the carcinogenicity of 2,6-dimethylaniline. There is sufficient evidence in experimental
animals for the carcinogenicity of 2,6-dimethylaniline. Overall evaluation: 2,6-dimethylaniline is possibly carcinogenic to humans (Group 2B).
Reproductive toxicity
no data available
STOT-single exposure
no data available
STOT-repeated exposure
no data available
Aspiration hazard
no data available
12.Ecological information
12.1 Toxicity
Toxicity to fish: no data available
Toxicity to daphnia and other aquatic invertebrates: no data available
Toxicity to algae: no data available
Toxicity to microorganisms: no data available
12.2 Persistence and degradability
AEROBIC: A Warburg respirometer study utilizing an activated sludge seed and 6 hr of incubation resulted in a 2,6-xylidine depletion of 33-37%
at a concentration of 20 ppm(1). In a 6 week soil degradation study using (14)C-labelled 2,6-xylidine, 8.4% of applied radioactivity was
recovered via CO2 evolution in non-autoclaved soil while 0% CO2 evolution occurred in autoclaved soil(2). In a soil degradation study conducted
in glass vessels using Chernozem soil, 2,6-xylidine (at 500 mg/L) was degraded after 3 days of incubation with >90% recovered in transformation
products(3). Using OECD Guideline 301F (Ready Biodegradability: Manometric Respirometry Test), 2,6-xylidine (at 100 mg/L) reached 4, 8,
25, 38 and 69% of its theoretical BOD after 7, 13, 36, 42 and 70 days. respectively(4); these results indicated that 2,6-xylidine was not readily
biodegradable according to OECD criteria, however, it is biodegradable after extended adaptation(4). In another OECD Guideline 301F study,
2,6-xylidine (at 100 mg/L) showed no bidegradation after 33 day(4). Using OECD Guideline 302B (Inherent biodegradability: Zahn-
Wellens/EMPA Test) and an industrial activated sludge seed, 83% of initial 2,6-xylidine was removed from the aqueous test system after 11 days,
however, the substance was mainly removed via volatilization(4). 2,6-Xylidine, present at 100 mg/L, reached 0% of its theoretical BOD in 4
weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(5).
12.3 Bioaccumulative potential
An estimated BCF value of 8 was calculated for 2,6-xylidine in fish(SRC), using a log Kow of 1.84(1) and a regression-derived equation(2).
According to a classification scheme(3), this BCF value suggests that bioconcentration in aquatic organisms is low(SRC).
12.4 Mobility in soil
Using a structure estimation method based on molecular connectivity indices(1), the Koc of 2,6-xylidine can be estimated to be 190(SRC).
According to a classification scheme(2), this estimated Koc value suggests that 2,6-xylidine is expected to have moderate mobility in soil. Aromatic
amines are expected to bind strongly to humus or organic matter in soils due to the high reactivity of the aromatic amino group(3,4), suggesting that
mobility may be lower in some soils(SRC). In a short term soil adsorption study using 14C-labelled 2,6-xylidine, 66% of the applied radioactivity
was bound to the soil (3.4% organic matter, 36.6% sand, 28.2% silt, 35.2% clay) after 24 hrs(3).
12.5 Other adverse effects
no data available
13.Disposal considerations
13.1 Disposal methods
Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not
contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it
unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible
packaging materials.
14.Transport information
14.1 UN Number
ADR/RID: UN1711IMDG: UN1711IATA: UN1711
14.2 UN Proper Shipping Name
ADR/RID: XYLIDINES, LIQUID
IMDG: XYLIDINES, LIQUID
IATA: XYLIDINES, LIQUID
14.3 Transport hazard class(es)
ADR/RID: 6.1IMDG: 6.1IATA: 6.1
14.4 Packing group, if applicable
ADR/RID: IIIMDG: IIIATA: II
14.5 Environmental hazards
ADR/RID: yesIMDG: yesIATA: yes
14.6 Special precautions for user
no data available
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
no data available
15.Regulatory information
15.1 Safety, health and environmental regulations specific for the product in question
Chemical name Common names and synonyms CAS number EC number
2,6-dimethylaniline 2,6-dimethylaniline 87-62-7 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC)Listed.
16.Other information
Information on revision
Creation Date Aug 12, 2017
Revision Date Aug 12, 2017
Abbreviations and acronyms
CAS: Chemical Abstracts Service
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
IMDG: International Maritime Dangerous Goods
IATA: International Air Transportation Association
TWA: Time Weighted Average
STEL: Short term exposure limit
LC50: Lethal Concentration 50%
LD50: Lethal Dose 50%
EC50: Effective Concentration 50%
References
IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website:
http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this
document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any
guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.