SAFETY DATA SHEETS
According to Globally Harmonized System of Classification and Labelling of
Chemicals (GHS) - Sixth revised edition
Version: 1.0
Creation Date: Aug 13, 2017
Revision Date: Aug 13, 2017
1.Identification
1.1 GHS Product identifier
Product name iodoacetic acid
1.2 Other means of identification
Product number-
Other names Iodoacetic acid
1.3 Recommended use of the chemical and restrictions on use
Identified uses For industry use only.
Uses advised againstno data available
1.4 Supplier's details
1.5 Emergency phone number
Emergency phone number-
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).
2.Hazard identification
2.1 Classification of the substance or mixture
Acute toxicity - Oral, Category 3
Skin corrosion, Category 1A
2.2 GHS label elements, including precautionary statements
Pictogram(s)
Signal word Danger
Hazard statement(s)
H301 Toxic if swallowed
H314 Causes severe skin burns and eye damage
Precautionary
statement(s)
Prevention
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
Response
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/…
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or
shower].
P363 Wash contaminated clothing before reuse.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P310 Immediately call a POISON CENTER/doctor/…
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and
easy to do. Continue rinsing.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to ...
2.3 Other hazards which do not result in classification
none
3.Composition/information on ingredients
3.1 Substances
Chemical name Common names and synonyms CAS numberEC numberConcentration
iodoacetic acid iodoacetic acid 64-69-7 none 100%
4.First-aid measures
4.1 Description of necessary first-aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
4.2 Most important symptoms/effects, acute and delayed
SYMPTOMS: Exposure to this compound may cause irritation of the skin, eyes and mucous membranes and may lead to contact dermatitis or
severe burns. ACUTE/CHRONIC HAZARDS: This material is capable of causing severe burns.
4.3 Indication of immediate medical attention and special treatment needed, if necessary
Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed.
Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat
if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye
continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water
for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after
decontamination ... . /Poison A and B/
5.Fire-fighting measures
5.1 Extinguishing media
Suitable extinguishing media
Fires involving this compound can be controlled with a dry chemical, carbon dioxide or Halon extinguisher.
5.2 Specific hazards arising from the chemical
Flash point data for this chemical are not available, but it is probably non-flammable.
5.3 Special protective actions for fire-fighters
Wear self-contained breathing apparatus for firefighting if necessary.
6.Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel
to safe areas. Avoid breathing dust. For personal protection see section 8.
6.2 Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.
6.3 Methods and materials for containment and cleaning up
Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.
7.Handling and storage
7.1 Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide
appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
8.Exposure controls/personal protection
8.1 Control parameters
Occupational Exposure limit values
no data available
Biological limit values
no data available
8.2 Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
8.3 Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection
Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government
standards such as NIOSH (US) or EN 166(EU).
Skin protection
Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous
substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without
touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable
laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive
89/686/EEC and the standard EN 374 derived from it.
Respiratory protection
Wear dust mask when handling large quantities.
Thermal hazards
no data available
9.Physical and chemical properties
Physical state white to light yellow crystalline powder
Colour Colorless or white crystals
Odour no data available
Melting point/ freezing point 79-83oC
Boiling point or initial boiling point and boiling range 208oC
Flammability no data available
Lower and upper explosion limit / flammability limit no data available
Flash point 208oC
Auto-ignition temperature no data available
Decomposition temperature no data available
pH no data available
Kinematic viscosity no data available
Solubility In water:600 g/L (20 oC)
Partition coefficient n-octanol/water (log value) no data available
Vapour pressure no data available
Density and/or relative density 2.2694 g/cm3 (85 C)
Relative vapour density no data available
Particle characteristics no data available
10.Stability and reactivity
10.1 Reactivity
no data available
10.2 Chemical stability
Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions
IODOACETIC ACID reacts vigorously with bases and is corrosive.
10.4 Conditions to avoid
no data available
10.5 Incompatible materials
no data available
10.6 Hazardous decomposition products
When heated to decomposition it emits toxic fumes of /iodine/.
11.Toxicological information
Acute toxicity
Oral: LD50 Mouse oral 83 mg/kg
Inhalation: no data available
Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
no data available
Reproductive toxicity
no data available
STOT-single exposure
no data available
STOT-repeated exposure
no data available
Aspiration hazard
no data available
12.Ecological information
12.1 Toxicity
Toxicity to fish: no data available
Toxicity to daphnia and other aquatic invertebrates: no data available
Toxicity to algae: no data available
Toxicity to microorganisms: no data available
12.2 Persistence and degradability
A single bacteria strain of Nocardia, isolated from soil, was able to readily bio-metabolize iodoacetic acid in a 20-day laboratory incubation
study(1); in contrast, a single strain of Pseudomonas was unable to metabolize iodoacetic acid(1).
12.3 Bioaccumulative potential
An estimated BCF of 3.2 was calculated for iodoacetic acid (SRC), using an estimated log Kow of 0.85(1) and a regression-derived equation(2).
According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
12.4 Mobility in soil
Using a structure estimation method based on molecular connectivity indices(1), the Koc for iodoacetic acid can be estimated to be 1.2(SRC).
According to a classification scheme(2), this estimated Koc value suggests that iodoacetic acid is expected to have very high mobility in soil. The
pKa of iodoacetic acid is 3.18(3), indicating that this compound will primarily exist as an anion in the environment and anions generally do not
adsorb more strongly to organic carbon and clay than their neutral counterparts(4).
12.5 Other adverse effects
no data available
13.Disposal considerations
13.1 Disposal methods
Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not
contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it
unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible
packaging materials.
14.Transport information
14.1 UN Number
ADR/RID: UN2923IMDG: UN2923IATA: UN2923
14.2 UN Proper Shipping Name
ADR/RID: CORROSIVE SOLID, TOXIC, N.O.S.
IMDG: CORROSIVE SOLID, TOXIC, N.O.S.
IATA: CORROSIVE SOLID, TOXIC, N.O.S.
14.3 Transport hazard class(es)
ADR/RID: 6.1IMDG: 6.1IATA: 6.1
14.4 Packing group, if applicable
ADR/RID: IIMDG: IIATA: I
14.5 Environmental hazards
ADR/RID: noIMDG: noIATA: no
14.6 Special precautions for user
no data available
14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
no data available
15.Regulatory information
15.1 Safety, health and environmental regulations specific for the product in question
Chemical name Common names and synonyms CAS number EC number
iodoacetic acid iodoacetic acid 64-69-7 none
European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
EC Inventory Listed.
United States Toxic Substances Control Act (TSCA) Inventory Listed.
China Catalog of Hazardous chemicals 2015 Listed.
New Zealand Inventory of Chemicals (NZIoC) Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS) Listed.
Vietnam National Chemical Inventory Not Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC)Listed.
16.Other information
Information on revision
Creation Date Aug 13, 2017
Revision Date Aug 13, 2017
Abbreviations and acronyms
CAS: Chemical Abstracts Service
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
IMDG: International Maritime Dangerous Goods
IATA: International Air Transportation Association
TWA: Time Weighted Average
STEL: Short term exposure limit
LC50: Lethal Concentration 50%
LD50: Lethal Dose 50%
EC50: Effective Concentration 50%
References
IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website:
http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this
document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any
guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.